A novel BH3 mimetic Bcl-2 inhibitor promotes autophagic cell death and reduces in vivo Glioblastoma tumor growth

Keyphrases

• Glioblastoma multiforme 100%
• B-cell Lymphoma 2 (Bcl-2) 100%
• Glioblastoma 100%
• Tumor Growth 100%
• BH3 Mimetics 100%
• Bcl-2 Inhibitor 100%
• Autophagic Cell Death 100%
• ABT-199 100%
• Cell Proliferation 33%
• Molecular Mechanism 33%
• Small Molecules 33%
• SH-SY5Y Cells 33%
• Apoptosis 33%
• LC3B 33%
• Autophagy Markers 33%
• Beclin-1 33%
• Cell Death 33%
• Brain Tumor 33%
• Glioblastoma Cells 33%
• 2-complex 33%
• Anti-apoptotic 33%
• Bcl-2 Family Proteins 33%
• High Affinity 33%
• 4-thiazolidinone Derivatives 33%
• Neuroblastoma 33%
• BECN1 33%
• Induced Apoptosis 33%
• Cancer Initiating Cells 33%
• A172 Cells 33%
• Computational Modeling 33%
• Vehicle Groups 33%
• Brain Tumor Model 33%
• Glioblastoma Therapy 33%
• ATG5 33%
• Model Simulation 33%
• Tumor Growth in Vivo 33%
• New Therapeutic Approaches 33%
• MAP1LC3B 33%

Neuroscience

• In Vivo 100%
• Bcl-2 100%
• Cell Death 100%
• Intracranial Tumor 40%
• Programmed Cell Death 40%
• Neuroblastoma 20%
• Cell Proliferation 20%
• In Vitro 20%
• Protein Family 20%
• Beclin 1 20%
• Autophagy 20%

Pharmacology, Toxicology and Pharmaceutical Science

• Glioblastoma 100%
• Tumor Growth 100%
• Intracranial Tumor 33%
• Antiapoptotic 16%
• Beclin 1 16%
• Neuroblastoma 16%
• Tumor Model 16%
• 4 Thiazolidinone Derivative 16%
• Drug Action 16%