TY - JOUR
T1 - Advancing bone tissue engineering
T2 - multi-walled carbon nanotube-polylactic acid composites for enhanced regeneration
AU - Zahedah, Rola
AU - Dinç, Bircan
N1 - Publisher Copyright:
© 2025 Informa UK Limited, trading as Taylor & Francis Group.
PY - 2025
Y1 - 2025
N2 - The regeneration of bone tissues using a composite-based tissue engineering approach is a promising strategy for repairing and restoring their biological functions. This study extensively investigates the development and potential applications of Multi-Walled Carbon Nanotube-Polylactic Acid (MWCNT-PLA) composites for bone defect healing. The scaffolds were meticulously engineered and characterized to assess their material properties, structural compatibility, biodegradability, pH impact, water absorption, biocompatibility, cell viability, and cellular interactions. Composites were characterized using scanning electron microscopy (SEM), differential scanning calorimetry (DSC), and Fourier transform infrared spectroscopy (FTIR). Results showed a 15% increase in glass transition temperature, a 20% improvement in cell adhesion, and a 25% enhancement in mechanical strength compared to pure PLA. HOB cells demonstrated increased adhesion and proliferation on the composites, highlighting their biocompatibility. The findings revealed that incorporating MWCNTs enhances the thermal and mechanical properties of PLA, promotes cell adhesion, and influences the degradation behavior of the nanocomposites, marking significant progress in bone tissue engineering.
AB - The regeneration of bone tissues using a composite-based tissue engineering approach is a promising strategy for repairing and restoring their biological functions. This study extensively investigates the development and potential applications of Multi-Walled Carbon Nanotube-Polylactic Acid (MWCNT-PLA) composites for bone defect healing. The scaffolds were meticulously engineered and characterized to assess their material properties, structural compatibility, biodegradability, pH impact, water absorption, biocompatibility, cell viability, and cellular interactions. Composites were characterized using scanning electron microscopy (SEM), differential scanning calorimetry (DSC), and Fourier transform infrared spectroscopy (FTIR). Results showed a 15% increase in glass transition temperature, a 20% improvement in cell adhesion, and a 25% enhancement in mechanical strength compared to pure PLA. HOB cells demonstrated increased adhesion and proliferation on the composites, highlighting their biocompatibility. The findings revealed that incorporating MWCNTs enhances the thermal and mechanical properties of PLA, promotes cell adhesion, and influences the degradation behavior of the nanocomposites, marking significant progress in bone tissue engineering.
KW - biocompatibility
KW - biodegradability
KW - human osteoblast cells
KW - multi-walled carbon nanotube
KW - nanocomposite
KW - Polylactic acid
UR - http://www.scopus.com/inward/record.url?scp=85214379432&partnerID=8YFLogxK
U2 - 10.1080/09276440.2025.2450158
DO - 10.1080/09276440.2025.2450158
M3 - Article
AN - SCOPUS:85214379432
SN - 0927-6440
JO - Composite Interfaces
JF - Composite Interfaces
ER -