Circulating fibroblast growth factor 23 in children on peritoneal dialysis is associated with effective dialysis

Duygu Övünç Hacıhamdioğlu, Ali Düzova, Dursun Alehan, Berna Oğuz, Nesrin Beşbaş

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)

Abstract

Our purpose was to assess the relationship between serum fibroblast growthfactor 23 (FGF23) and left ventricular function, carotid intima-media thickness(CIMT) and laboratory features in children on peritoneal dialysis (PD).The study population consisted of 17 patients (11 female; median age 7.83years, range 0.66-17.75) undergoing PD for 22 months (range 2-98). SerumFGF23, serum phosphorus, calcium, intact parathyroid hormone (iPTH),25(OH) vitamin D, 1,25(OH)2 vitamin D and Kt/V urea, left ventricular mass(LVM) and LVM index (LVMI) were assessed.Median FGF23 level was 29.92 pg/ml (22.7-74.76), phosphorus was 5.2 mg/dl(3.1-9.9), iPTH was 438 pg/ml (16-1446), 25(OH) vitamin D was 11 ng/ml(5-35), 1,25(OH)2 vitamin D was 11 pg/ml (2-106), Kt/V urea was 2.33 (1.01-3.84). FGF23 level was independently associated with Kt/V urea (p<0.001).We found that effective dialysis may be the leading determinant of FGF level,independent from the calcium-phosphorus-PTH axis, in pediatric PD patients.

Original languageEnglish
Pages (from-to)9-16
Number of pages8
JournalTurkish Journal of Pediatrics
Volume57
Issue number1
Publication statusPublished - 29 Sept 2015
Externally publishedYes

Keywords

  • CIMT
  • FGF23
  • Kt/V urea
  • Left ventricular hypertrophy

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