Epstein-Barr virus-related lymphoproliferative disorders in T-cell repleted haploidentical transplantation with post-transplant cyclophosphamide

Vedat Uygun; Nazan Özsan; Hayriye Daloğlu; Seda Öztürkmen; Koray Yalçın; Gülsün Karasu; Akif Yeşilipek

doi:10.1007/s12185-021-03267-8

Epstein-Barr virus-related lymphoproliferative disorders in T-cell repleted haploidentical transplantation with post-transplant cyclophosphamide

Vedat Uygun, Nazan Özsan, Hayriye Daloğlu, Seda Öztürkmen, Koray Yalçın, Gülsün Karasu, Akif Yeşilipek

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Abstract

EBV-associated lymphoproliferative disorders (LPDs) are common in hematopoietic stem cell transplantation (HSCT) with T-cell-depleted grafts, but are extremely rare in HSCT patients with T-cell-replete grafts with post-transplant cyclophosphamide (PTCy). Here we present the cases of two pediatric patients who developed EBV-related LPD after T-cell-replete haplo-HSCT with PTCy. One of these is the first reported case of EBV-positive mucocutaneous ulcer (EBVMCU) developing after PTCy. EBV-related diseases are rare in T-cell-replete haplo-HSCT patients with PTCy. However, in patients with risk factors, it is reasonable to screen for EBV viremia for LPD.

Original language	English
Pages (from-to)	600-604
Number of pages	5
Journal	International Journal of Hematology
Volume	115
Issue number	4
DOIs	https://doi.org/10.1007/s12185-021-03267-8
Publication status	Published - Apr 2022

Keywords

EBV-positive mucocutaneous ulcer
Epstein–Barr virus
Lymphoproliferative disorder
Post-transplant cyclophosphamide

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10.1007/s12185-021-03267-8

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@article{ce78152be31c468bb5354aa2fd208850,

title = "Epstein-Barr virus-related lymphoproliferative disorders in T-cell repleted haploidentical transplantation with post-transplant cyclophosphamide",

abstract = "EBV-associated lymphoproliferative disorders (LPDs) are common in hematopoietic stem cell transplantation (HSCT) with T-cell-depleted grafts, but are extremely rare in HSCT patients with T-cell-replete grafts with post-transplant cyclophosphamide (PTCy). Here we present the cases of two pediatric patients who developed EBV-related LPD after T-cell-replete haplo-HSCT with PTCy. One of these is the first reported case of EBV-positive mucocutaneous ulcer (EBVMCU) developing after PTCy. EBV-related diseases are rare in T-cell-replete haplo-HSCT patients with PTCy. However, in patients with risk factors, it is reasonable to screen for EBV viremia for LPD.",

keywords = "EBV-positive mucocutaneous ulcer, Epstein–Barr virus, Lymphoproliferative disorder, Post-transplant cyclophosphamide",

author = "Vedat Uygun and Nazan {\"O}zsan and Hayriye Daloğlu and Seda {\"O}zt{\"u}rkmen and Koray Yal{\c c}ın and G{\"u}ls{\"u}n Karasu and Akif Ye{\c s}ilipek",

note = "Publisher Copyright: {\textcopyright} 2021, Japanese Society of Hematology.",

year = "2022",

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doi = "10.1007/s12185-021-03267-8",

language = "English",

volume = "115",

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T1 - Epstein-Barr virus-related lymphoproliferative disorders in T-cell repleted haploidentical transplantation with post-transplant cyclophosphamide

AU - Uygun, Vedat

AU - Özsan, Nazan

AU - Daloğlu, Hayriye

AU - Öztürkmen, Seda

AU - Yalçın, Koray

AU - Karasu, Gülsün

AU - Yeşilipek, Akif

PY - 2022/4

Y1 - 2022/4

N2 - EBV-associated lymphoproliferative disorders (LPDs) are common in hematopoietic stem cell transplantation (HSCT) with T-cell-depleted grafts, but are extremely rare in HSCT patients with T-cell-replete grafts with post-transplant cyclophosphamide (PTCy). Here we present the cases of two pediatric patients who developed EBV-related LPD after T-cell-replete haplo-HSCT with PTCy. One of these is the first reported case of EBV-positive mucocutaneous ulcer (EBVMCU) developing after PTCy. EBV-related diseases are rare in T-cell-replete haplo-HSCT patients with PTCy. However, in patients with risk factors, it is reasonable to screen for EBV viremia for LPD.

AB - EBV-associated lymphoproliferative disorders (LPDs) are common in hematopoietic stem cell transplantation (HSCT) with T-cell-depleted grafts, but are extremely rare in HSCT patients with T-cell-replete grafts with post-transplant cyclophosphamide (PTCy). Here we present the cases of two pediatric patients who developed EBV-related LPD after T-cell-replete haplo-HSCT with PTCy. One of these is the first reported case of EBV-positive mucocutaneous ulcer (EBVMCU) developing after PTCy. EBV-related diseases are rare in T-cell-replete haplo-HSCT patients with PTCy. However, in patients with risk factors, it is reasonable to screen for EBV viremia for LPD.

KW - EBV-positive mucocutaneous ulcer

KW - Epstein–Barr virus

KW - Lymphoproliferative disorder

KW - Post-transplant cyclophosphamide

UR - https://www.scopus.com/pages/publications/85119955552

U2 - 10.1007/s12185-021-03267-8

DO - 10.1007/s12185-021-03267-8

M3 - Article

C2 - 34826107

AN - SCOPUS:85119955552

SN - 0925-5710

VL - 115

SP - 600

EP - 604

JO - International Journal of Hematology

JF - International Journal of Hematology

IS - 4

ER -

Epstein-Barr virus-related lymphoproliferative disorders in T-cell repleted haploidentical transplantation with post-transplant cyclophosphamide

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