Evaluation of lipid peroxidation and antioxidant system in healthy iron-replete infants receiving iron prophylaxis

Duygu Övunc Hacihamdioglu, A. Emin Kurekci, Orhan Gursel, A. Avni Atay, Necati Balamtekin, Ahmet Aydin, Adnan Haşimi, Okan Ozcan

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)

Abstract

Objective: Iron supplementation is commonly recommended for infants; however, there are some reports that it causes oxidative damage. The aim of this study was to investigate the potential effects of iron supplementation at 4 mo of age, for a period of 2 mo, on lipid peroxidation and free radical scavenging enzymes. Methods: Twenty-seven healthy 4-mo-old infants chosen randomly and given iron supplementation (ferrous sulfate, 10 mg of elemental iron per day) constituted the study group and 26 healthy 4-mo-old infants who were chosen randomly and not given iron supplementation constituted the control group. Weight, height, head circumference, complete blood cell count, serum ferritin level and intraerythrocytic zinc, iron, copper, malondialdehyde, catalase, superoxide dismutase, and glutathione peroxidase levels were measured in the two groups at 4 and 6 mo of life. Results: Compared with controls at 6 mo of age, no significant differences were observed for intraerythrocytic zinc (0.5 ± 0.1 versus 0.6 ± 0.2 μg/mL, P > 0.05), copper (0.2 ± 0.1 versus 0.2 ± 0.2 μg/mL, P > 0.05), iron (130.8 ± 10.9 versus 127.4 ± 11.1 μg/mL, P > 0.05), malondialdehyde (21.4 ± 3.5 versus 22.4 ± 2.3 nmol/g of hemoglobin, P > 0.05), catalase (135.4 ± 23.9 versus 135.1 ± 23.3 MU/g of hemoglobin, P > 0.05), superoxide dismutase (1736.4 ± 141.1 versus 1701.3 ± 103.9 U/g of hemoglobin, P > 0.05), and glutathione peroxidase (8.9 ± 1.6 versus 8.4 ± 1.6 U/g of hemoglobin, P > 0.05) levels. Conclusion: Our study indicates that the supplemental use of elemental iron 10 mg/d for a period of 2 mo in healthy iron-replete infants did not cause lipid peroxidation or an impairment of antioxidant status.

Original languageEnglish
Pages (from-to)138-142
Number of pages5
JournalNutrition
Volume29
Issue number1
DOIs
Publication statusPublished - Jan 2013
Externally publishedYes

Keywords

  • Antioxidant system
  • Infant
  • Iron prophylaxis
  • Lipid peroxidation

Fingerprint

Dive into the research topics of 'Evaluation of lipid peroxidation and antioxidant system in healthy iron-replete infants receiving iron prophylaxis'. Together they form a unique fingerprint.

Cite this