iCELLigence real-time cell analysis system for examining the cytotoxicity of drugs to cancer cell lines

Leyla Türker Şener; Gürcan Albeniz; Bircan Dinç; Işil Albeniz

doi:10.3892/etm.2017.4781

iCELLigence real-time cell analysis system for examining the cytotoxicity of drugs to cancer cell lines

Leyla Türker Şener, Gürcan Albeniz, Bircan Dinç, Işil Albeniz

Research output: Contribution to journal › Review article › peer-review

48 Citations (Scopus)

Abstract

The recently developed iCELLigence™ real-time cell analyzer (RTCA) can be used for the label-free real-time monitoring of cancer cell proliferation, viability, invasion and cytotoxicity. The RTCA system uses 16-well microtiter plates with a gold microelectrode biosensor array that measures impedance when cells adhere to the microelectrodes causing an alternating current. By measuring the electric field generated in this process, the RTCA system can be used for the analysis of cell proliferation, viability, morphology and migration. The present review aimed to summarize the working method of the RTCA system, in addition to discussing the research performed using the system for various applications, including cancer drug discovery via measuring cytotoxicity.

Original language	English
Pages (from-to)	1866-1870
Number of pages	5
Journal	Experimental and Therapeutic Medicine
Volume	14
Issue number	3
DOIs	https://doi.org/10.3892/etm.2017.4781
Publication status	Published - 2017
Externally published	Yes

Keywords

Cellular impedance
Cytotoxicity
MCF-7
MDA-MB-231
Proliferation
iCELLigence
xCELLigence

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.3892/etm.2017.4781

Cite this

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title = "iCELLigence real-time cell analysis system for examining the cytotoxicity of drugs to cancer cell lines",

abstract = "The recently developed iCELLigence{\texttrademark} real-time cell analyzer (RTCA) can be used for the label-free real-time monitoring of cancer cell proliferation, viability, invasion and cytotoxicity. The RTCA system uses 16-well microtiter plates with a gold microelectrode biosensor array that measures impedance when cells adhere to the microelectrodes causing an alternating current. By measuring the electric field generated in this process, the RTCA system can be used for the analysis of cell proliferation, viability, morphology and migration. The present review aimed to summarize the working method of the RTCA system, in addition to discussing the research performed using the system for various applications, including cancer drug discovery via measuring cytotoxicity.",

keywords = "Cellular impedance, Cytotoxicity, MCF-7, MDA-MB-231, Proliferation, iCELLigence, xCELLigence",

author = "{\c S}ener, {Leyla T{\"u}rker} and G{\"u}rcan Albeniz and Bircan Din{\c c} and I{\c s}il Albeniz",

year = "2017",

doi = "10.3892/etm.2017.4781",

language = "English",

volume = "14",

pages = "1866--1870",

journal = "Experimental and Therapeutic Medicine",

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T1 - iCELLigence real-time cell analysis system for examining the cytotoxicity of drugs to cancer cell lines

AU - Şener, Leyla Türker

AU - Albeniz, Gürcan

AU - Dinç, Bircan

AU - Albeniz, Işil

PY - 2017

Y1 - 2017

N2 - The recently developed iCELLigence™ real-time cell analyzer (RTCA) can be used for the label-free real-time monitoring of cancer cell proliferation, viability, invasion and cytotoxicity. The RTCA system uses 16-well microtiter plates with a gold microelectrode biosensor array that measures impedance when cells adhere to the microelectrodes causing an alternating current. By measuring the electric field generated in this process, the RTCA system can be used for the analysis of cell proliferation, viability, morphology and migration. The present review aimed to summarize the working method of the RTCA system, in addition to discussing the research performed using the system for various applications, including cancer drug discovery via measuring cytotoxicity.

AB - The recently developed iCELLigence™ real-time cell analyzer (RTCA) can be used for the label-free real-time monitoring of cancer cell proliferation, viability, invasion and cytotoxicity. The RTCA system uses 16-well microtiter plates with a gold microelectrode biosensor array that measures impedance when cells adhere to the microelectrodes causing an alternating current. By measuring the electric field generated in this process, the RTCA system can be used for the analysis of cell proliferation, viability, morphology and migration. The present review aimed to summarize the working method of the RTCA system, in addition to discussing the research performed using the system for various applications, including cancer drug discovery via measuring cytotoxicity.

KW - Cellular impedance

KW - Cytotoxicity

KW - MCF-7

KW - MDA-MB-231

KW - Proliferation

KW - iCELLigence

KW - xCELLigence

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DO - 10.3892/etm.2017.4781

M3 - Review article

AN - SCOPUS:85026649914

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JO - Experimental and Therapeutic Medicine

JF - Experimental and Therapeutic Medicine

IS - 3

ER -

iCELLigence real-time cell analysis system for examining the cytotoxicity of drugs to cancer cell lines

Abstract

Keywords

UN SDGs

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