Left Atrial Function by Speckle-Tracking Echocardiography in Chronic Asymptomatic Alcoholic Patients

Gonenc Kocabay, Can Yucel Karabay, Arzu Kalaycı, Vecih Oduncu, Taylan Akgun, Ahmet Guler, Alev Kılıcgedik, Sedat Kalkan, Akin İzgi, Cevat Kırma

Research output: Contribution to journalArticlepeer-review

9 Citations (Scopus)

Abstract

Although the effects of chronic alcoholism on left ventricular (LV) systolic function are well established, diastolic impairment has been evaluated partially. In addition, there are scarce data available about the relation of LV diastolic function to either or both duration and quantity of drinking among alcoholics. The aim of the study was to evaluate the left atrial (LA) function in chronic asymptomatic alcoholic patients by using two-dimensional speckle-tracking echocardiography (2D-STE). We enrolled 30 healthy subjects (age 34.8 ± 5.8 years) and 75 asymptomatic male alcoholics (age 39.8 ± 6.5 years) divided into two groups, according to total lifetime dose of ethanol: group I, <15 kg/kg and group II, ≥15 kg/kg. In the 2D-STE analysis of the LA, strain during ventricular systole (LA-Res), during late diastole (LA-Pump) and strain rate during ventricular contraction (LA-SRs), during passive ventricular filling (LA-SRe), during active atrial contraction (LA-SRa) were obtained. Deceleration time was longer, E/A and Vp were smaller, and E/Em was higher in alcoholics. Although parameters of diastolic dysfunction were comparable in alcoholic groups, LA-Res and LA-Pump were found significantly different among the alcoholics. However, there were no differences in LA-SRs and LA-SRe between the controls and alcoholic groups. LA function is reduced in chronic alcohol abuse, and heavy alcohol consumption may play an important role in LA function impairment.

Original languageEnglish
Pages (from-to)189-196
Number of pages8
JournalCardiovascular Toxicology
Volume15
Issue number2
DOIs
Publication statusPublished - Apr 2015
Externally publishedYes

Keywords

  • Chronic asymptomatic alcoholic patients
  • LV diastolic dysfunction
  • Left atrial function
  • Speckle-tracking echocardiography

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