TY - GEN
T1 - MRI of a Surgical Guidewire in a Hydrogel Phantom
T2 - 2023 Medical Technologies Congress, TIPTEKNO 2023
AU - Baysoy, Engin
AU - Ayan, Bugra
AU - Kaleli-Can, Gizem
AU - Buyuksarac, Bora
AU - Liu, Chunlei
N1 - Publisher Copyright:
© 2023 IEEE.
PY - 2023
Y1 - 2023
N2 - Magnetic resonance imaging (MRI) presents an alternative imaging method over conventional X-ray based modalities for guiding minimal invasive surgeries. However, lack of commercial MRI safe and functional interventional instruments and devices is the main obstacle for the realization of interventional procedures under MRI. Herein, as a novel passive tracking method, Fe3+ ions binded melanin nanoparticles (MNPs) were used as a coating to enhance the visibility of a commercial MRI safe nitinol guidewire. Fe3+ chelating ability of MNPs was found to be approximately 95% using inductively coupled plasma mass spectroscopy (ICP-MS). The spherical shapes of MNPs were evaluated and measured by scanning electron analysis with a mean diameter of 134± 21 nm for MNPs before $Fe3+ chelation and $144 ± 34$ nm after. NIH 3T3 cells incubated with MNPs-Fe3+ solutions at levels up to 1000 ng/ml and MNPs-Fe3+ solutions indicated negligible cytotoxic effect. The traceability of MNPs-Fe+ coated surgical nitinol guidewire was confirmed inside a custom-made hydrogel phantom model in a 3T MRI scanner. A conspicuous bright signal from coated nitinol guidewire was obtained for axial, sagittal, and coronal planes with MRI. This pilot study showed that both the tracking of an interventional guidewire and the degradation level of a hydrogel used for the therapeutic response of a drug can be imaged by MRI during minimal invasive operations.
AB - Magnetic resonance imaging (MRI) presents an alternative imaging method over conventional X-ray based modalities for guiding minimal invasive surgeries. However, lack of commercial MRI safe and functional interventional instruments and devices is the main obstacle for the realization of interventional procedures under MRI. Herein, as a novel passive tracking method, Fe3+ ions binded melanin nanoparticles (MNPs) were used as a coating to enhance the visibility of a commercial MRI safe nitinol guidewire. Fe3+ chelating ability of MNPs was found to be approximately 95% using inductively coupled plasma mass spectroscopy (ICP-MS). The spherical shapes of MNPs were evaluated and measured by scanning electron analysis with a mean diameter of 134± 21 nm for MNPs before $Fe3+ chelation and $144 ± 34$ nm after. NIH 3T3 cells incubated with MNPs-Fe3+ solutions at levels up to 1000 ng/ml and MNPs-Fe3+ solutions indicated negligible cytotoxic effect. The traceability of MNPs-Fe+ coated surgical nitinol guidewire was confirmed inside a custom-made hydrogel phantom model in a 3T MRI scanner. A conspicuous bright signal from coated nitinol guidewire was obtained for axial, sagittal, and coronal planes with MRI. This pilot study showed that both the tracking of an interventional guidewire and the degradation level of a hydrogel used for the therapeutic response of a drug can be imaged by MRI during minimal invasive operations.
KW - Natural melanin nanoparticles
KW - hydrogel phantom
KW - interventional MRI
KW - magnetic resonance imaging (MRI)
UR - http://www.scopus.com/inward/record.url?scp=85182742265&partnerID=8YFLogxK
U2 - 10.1109/TIPTEKNO59875.2023.10359187
DO - 10.1109/TIPTEKNO59875.2023.10359187
M3 - Conference contribution
AN - SCOPUS:85182742265
T3 - TIPTEKNO 2023 - Medical Technologies Congress, Proceedings
BT - TIPTEKNO 2023 - Medical Technologies Congress, Proceedings
PB - Institute of Electrical and Electronics Engineers Inc.
Y2 - 10 November 2023 through 12 November 2023
ER -