TY - JOUR
T1 - Neuronavigated rTMS inhibition of right pars triangularis anterior in stuttering
T2 - Differential effects on reading and speaking
AU - Tezel-Bayraktaroglu, Oyku
AU - Bayraktaroglu, Zubeyir
AU - Demirtas-Tatlidede, Asli
AU - Demiralp, Tamer
AU - Oge, A. Emre
N1 - Publisher Copyright:
© 2020
PY - 2020/11
Y1 - 2020/11
N2 - Functional neuroimaging studies show an overactivation of speech and language related homologous areas of the right hemisphere in persons who stutter. In this study, we inhibited Broca's homologues using 1 Hz repetitive transcranial magnetic stimulation (rTMS) and assessed its effects on stuttering severity. The investigated cortical areas included pars opercularis (BA44), anterior and posterior pars triangularis (BA45), mouth area on the primary motor cortex (BA4). We collected reading and speaking samples before and after rTMS sessions and calculated the percentage of syllables stuttered. Only right anterior pars triangularis stimulation induced significant changes in speech fluency. Notably, the effects were differential for reading and speaking conditions. Overall, our results provide supportive evidence that right anterior BA45 may be a critical region for stuttering. The observed differential effects following the inhibition of right anterior BA45 merits further study of contributions of this region on different language domains in persons who stutter.
AB - Functional neuroimaging studies show an overactivation of speech and language related homologous areas of the right hemisphere in persons who stutter. In this study, we inhibited Broca's homologues using 1 Hz repetitive transcranial magnetic stimulation (rTMS) and assessed its effects on stuttering severity. The investigated cortical areas included pars opercularis (BA44), anterior and posterior pars triangularis (BA45), mouth area on the primary motor cortex (BA4). We collected reading and speaking samples before and after rTMS sessions and calculated the percentage of syllables stuttered. Only right anterior pars triangularis stimulation induced significant changes in speech fluency. Notably, the effects were differential for reading and speaking conditions. Overall, our results provide supportive evidence that right anterior BA45 may be a critical region for stuttering. The observed differential effects following the inhibition of right anterior BA45 merits further study of contributions of this region on different language domains in persons who stutter.
KW - Broca's homologue
KW - Inferior Frontal Gyrus
KW - Pars Opercularis
KW - Pars Triangularis
KW - Percentage of Syllables Stuttered
KW - Reading
KW - Repetitive Transcranial Magnetic Stimulation
KW - Speaking
KW - Speech Fluency
KW - Stuttering
UR - http://www.scopus.com/inward/record.url?scp=85091203369&partnerID=8YFLogxK
U2 - 10.1016/j.bandl.2020.104862
DO - 10.1016/j.bandl.2020.104862
M3 - Article
C2 - 32979643
AN - SCOPUS:85091203369
SN - 0093-934X
VL - 210
JO - Brain and Language
JF - Brain and Language
M1 - 104862
ER -