Pathophysiology of adhesion formation and strategies for prevention

Victor Gomel, Bülent Urman, Timur Gürgan

Research output: Contribution to journalArticlepeer-review

86 Citations (Scopus)

Abstract

OBJECTIVE: To review the mechanism of adhesion formation and to briefly discuss the possible sites of action of various preventive measures and adjuvants. STUDY DESIGN: Literature review. RESULTS: Although good surgical technique, designed to minimize trauma, is a crucial part of adhesion prevention, technique alone cannot effectively eliminate de novo formation and especially reformation of adhesions. CONCLUSION: To date, no adjuvant has proven uniformly effective in preventing postoperative adhesions. Nonreactive barriers show promise in selected situations, especially in the presence of apposing, injured peritoneal surfaces. Development of new and more effective compounds and advances in molecular cell biology may provide a more definitive answer to this perplexing problem, which has eluded surgeons for so long.

Original languageEnglish
Pages (from-to)35-41
Number of pages7
JournalJournal of Reproductive Medicine
Volume41
Issue number1
Publication statusPublished - 1996

Keywords

  • adhesions

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