Plasma bisphenol a and phthalate levels in children with cerebral palsy: a case-control study

Özlem Tezol, Sıddıka Songül Yalçin, Anıl Yirün, Aylin Balci Özyurt, Çetin Okuyaz, Pınar Erkekoğlu

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

The case-control study aimed to evaluate potential sources of exposure and the plasma concentrations of bisphenol A (BPA) and phthalates in prepubertal children having cerebral palsy (CP) and healthy control. Blood samples of 68 CP and 70 controls were analyzed for BPA, di-(2-ethylhexyl)-phthalate (DEHP), mono-(2-ethylhexyl)-phthalate (MEHP), and dibutyl phthalate (DBP). BPA and DBP levels were similar in groups. The median DEHP and MEHP levels of the children with CP were significantly lower than those of the controls (p = 0.035, p < 0.001, respectively). Exposure to plastic food containers/bags, personal care hygiene products, household cleaners, wood/coal stove heating, and city water supplies were associated with increased odds of higher BPA and phthalate levels in children with CP. In conclusion, potential exposure sources for BPA and phthalates differ in children with CP and healthy controls, and children with CP are not exposed to higher levels of BPA and phthalates.

Original languageEnglish
Pages (from-to)499-513
Number of pages15
JournalInternational Journal of Environmental Health Research
Volume34
Issue number1
DOIs
Publication statusPublished - 2024
Externally publishedYes

Keywords

  • BPA
  • Cerebral palsy
  • children
  • phthalate

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