TY - JOUR
T1 - Prognostic Value of Neutrophil-to-Lymphocyte Ratio for Patients Undergoing Heart Valve Replacement
AU - Sinan Guvenc, Tolga
AU - Ekmekci, Ahmet
AU - Uluganyan, Mahmut
AU - Ertas, Gokhan
AU - Betul Erer, Hatice
AU - Ozpamuk Karadeniz, Fatma
AU - Tanik, Ozan
AU - Oz, Ahmet
AU - Kocogullari, Cevdet
AU - Velibey, Yalcin
AU - Karaca, Gurkan
AU - Eren, Mehmet
PY - 2016/5/1
Y1 - 2016/5/1
N2 - BACKGROUND AND AIM OF THE STUDY: The neutrophil-tolymphocyte ratio (NLR) was found to be a predictor of adverse outcome in patients with coronary artery disease (CAD). The ratio may also be a useful marker to predict mortality following valve replacement surgery.METHODS: A total of 932 patients was enrolled retrospectively. Patients were allocated to three tertiles based on their NLR (group 1, NLR ≤1.90; group 2, 1.90 < NLR ≤2.93; group 3, NLR >2.93).RESULTS: Patients in the highest tertile were older (p = 0.049, 95% CI 0.09-5.98), tended to have chronic renal failure (p = 0.028, OR: 2.6, 95% CI 1.08-6.35), and had more frequent critical CAD on preoperative angiography (p <0.001, OR 2.1, 95% CI 1.38-3.21). Postoperatively, patients in the highest NLR tertile had a higher in-hospital mortality rate than those in the first tertile (p <0.001, OR 4.67, 95% CI 2.37-9.20) and second tertile (p = 0.002, OR 2.26, 95% CI 1.32-3.86). Patients in the third tertile had the highest mortality at day 300 (log-rank p <0.001). The hazard ratio (HR) for the second tertile was 1.8 (p = 0.11, 95% CI 0.88-3.79), and for the third tertile was 2.8 (p = 0.003, 95% CI 1.40-5.59).CONCLUSIONS: The NLR is a useful parameter to assess postoperative in-hospital mortality risk after valvular surgery.
AB - BACKGROUND AND AIM OF THE STUDY: The neutrophil-tolymphocyte ratio (NLR) was found to be a predictor of adverse outcome in patients with coronary artery disease (CAD). The ratio may also be a useful marker to predict mortality following valve replacement surgery.METHODS: A total of 932 patients was enrolled retrospectively. Patients were allocated to three tertiles based on their NLR (group 1, NLR ≤1.90; group 2, 1.90 < NLR ≤2.93; group 3, NLR >2.93).RESULTS: Patients in the highest tertile were older (p = 0.049, 95% CI 0.09-5.98), tended to have chronic renal failure (p = 0.028, OR: 2.6, 95% CI 1.08-6.35), and had more frequent critical CAD on preoperative angiography (p <0.001, OR 2.1, 95% CI 1.38-3.21). Postoperatively, patients in the highest NLR tertile had a higher in-hospital mortality rate than those in the first tertile (p <0.001, OR 4.67, 95% CI 2.37-9.20) and second tertile (p = 0.002, OR 2.26, 95% CI 1.32-3.86). Patients in the third tertile had the highest mortality at day 300 (log-rank p <0.001). The hazard ratio (HR) for the second tertile was 1.8 (p = 0.11, 95% CI 0.88-3.79), and for the third tertile was 2.8 (p = 0.003, 95% CI 1.40-5.59).CONCLUSIONS: The NLR is a useful parameter to assess postoperative in-hospital mortality risk after valvular surgery.
UR - http://www.scopus.com/inward/record.url?scp=85047769488&partnerID=8YFLogxK
M3 - Article
C2 - 27989052
AN - SCOPUS:85047769488
SN - 0966-8519
VL - 25
SP - 389
EP - 396
JO - Journal of Heart Valve Disease
JF - Journal of Heart Valve Disease
IS - 3
ER -