Reversible posterior leukoencephalopathy syndrome due to intrathecal methotrexate in a case with acute lymphoblastic leukemia

Reversible posterior leukoencephalopathy syndrome is characterized by headache, nausea, seizures, altered consciousness, visual disturbance, and convulsion. It usually develops due to hypertension, eclampsia, autoimmune diseases, blood transfusion, hypercalcemia, hypomagnesemia, and immunosuppressive therapy. The radiological feature of this syndrome is reversible bilateral white matter abnormalities predominantly located in the posterior regions of the cerebral hemispheres. With symptomatic therapy, clinical and radiologic recovery can be achieved. In this case report, we aimed to present clinical and radiological fndings of transient posterior leukoencephalopathy syndrome due to intrathecal methotrexate usage in a case with acute lymphoblastic leukemia.