SARS-CoV-2 isolation and propagation from turkish COVID-19 patients

Cihan Taştan, Bulut Yurtsever, Gözde Sir Karakuş, Derya Dilek Kançaği, Sevda Demir, Selen Abanuz, Utku Seyis, Mülazim Yildirim, Recai Kuzay, Ömer Elibol, Serap Arbak, Merve Açikel Elmas, Selçuk Birdoğan, Osman Uğur Sezerman, Ayşe Sesin Kocagöz, Koray Yalçin, Ercüment Ovali

Research output: Contribution to journalArticlepeer-review

21 Citations (Scopus)

Abstract

The novel coronavirus pneumonia, which was named later as coronavirus disease 2019 (COVID-19), is caused by the severe acute respiratory syndrome coronavirus 2, namely SARS-CoV-2. It is a positive-strand RNA virus that is the seventh coronavirus known to infect humans. The COVID-19 outbreak presents enormous challenges for global health behind the pandemic outbreak. The first diagnosed patient in Turkey has been reported by the Republic of Turkey Ministry of Health on March 11, 2020. In May, over 150,000 cases in Turkey, and 5.5 million cases around the world have been declared. Due to the urgent need for a vaccine and antiviral drug, isolation of the virus is crucial. Here, we report 1 of the first isolation and characterization studies of SARS-CoV-2 from nasopharyngeal and oropharyngeal specimens of diagnosed patients in Turkey. This study provides an isolation and replication methodology,and cell culture tropism of the virus that will be available to the research communities.

Original languageEnglish
Pages (from-to)192-202
Number of pages11
JournalTurkish Journal of Biology
Volume44
Issue numberSpecial issue 1
DOIs
Publication statusPublished - 2020
Externally publishedYes

Keywords

  • COVID-19
  • Coronavirus
  • SARS-CoV-2

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