The relationship between urine heat shock protein 70 and congenital anomalies of the kidney and urinary tract: UTILISE study

Bagdagul Aksu; Alberto Caldas Afonso; Ipek Akil; Harika Alpay; Bahriye Atmis; Ozlem Aydog; Sevcan Bakkaloglu; Aysun Karabay Bayazıt; Meral Torun Bayram; Ilmay Bilge; Ipek Kaplan Bulut; Ayse Pinar Goksu Cetinkaya; Elif Comak; Belde Kasap Demir; Nida Dincel; Osman Donmez; Mehmet Akif Durmus; Hasan Dursun; Ruhan Dusunsel; Ali Duzova; Pelin Ertan; Asuman Gedikbasi; Nilufer Goknar; Sercin Guven; Duygu Hacihamdioglu; Augustina Jankauskiene; Mukaddes Kalyoncu; Salih Kavukcu; Bahriye Uzun Kenan; Nuran Kucuk; Bahar Kural; Mieczysław Litwin; Giovanni Montini; William Morello; Lukasz Obrycki; Beyhan Omer; Ebru Misirli Ozdemir; Nese Ozkayin; Dusan Paripovic; Cemile Pehlivanoglu; Seha Saygili; Franz Schaefer; Susanne Schaefer; Ferah Sonmez; Yilmaz Tabel; Nesrin Tas; Mehmet Tasdemir; Ana Teixeira; Demet Tekcan; Rezan Topaloglu; Sebahat Tulpar; Ozde Nisa Turkkan; Berfin Uysal; Metin Uysalol; Renata Vitkevic; Sevgi Yavuz; Sibel Yel; Tarik Yildirim; Zeynep Yuruk Yildirim; Nurdan Yildiz; Selcuk Yuksel; Eray Yurtseven; Alev Yilmaz

doi:10.3389/fruro.2023.1281081

The relationship between urine heat shock protein 70 and congenital anomalies of the kidney and urinary tract: UTILISE study

Bagdagul Aksu, Alberto Caldas Afonso, Ipek Akil, Harika Alpay, Bahriye Atmis, Ozlem Aydog, Sevcan Bakkaloglu, Aysun Karabay Bayazıt, Meral Torun Bayram, Ilmay Bilge, Ipek Kaplan Bulut, Ayse Pinar Goksu Cetinkaya, Elif Comak, Belde Kasap Demir, Nida Dincel, Osman Donmez, Mehmet Akif Durmus, Hasan Dursun, Ruhan Dusunsel, Ali DuzovaPelin Ertan, Asuman Gedikbasi, Nilufer Goknar, Sercin Guven, Duygu Hacihamdioglu, Augustina Jankauskiene, Mukaddes Kalyoncu, Salih Kavukcu, Bahriye Uzun Kenan, Nuran Kucuk, Bahar Kural, Mieczysław Litwin, Giovanni Montini, William Morello, Lukasz Obrycki, Beyhan Omer, Ebru Misirli Ozdemir, Nese Ozkayin, Dusan Paripovic, Cemile Pehlivanoglu, Seha Saygili, Franz Schaefer, Susanne Schaefer, Ferah Sonmez, Yilmaz Tabel, Nesrin Tas, Mehmet Tasdemir, Ana Teixeira, Demet Tekcan, Rezan Topaloglu, Sebahat Tulpar, Ozde Nisa Turkkan, Berfin Uysal, Metin Uysalol, Renata Vitkevic, Sevgi Yavuz, Sibel Yel, Tarik Yildirim, Zeynep Yuruk Yildirim, Nurdan Yildiz, Selcuk Yuksel, Eray Yurtseven, Alev Yilmaz

Research output: Contribution to journal › Article › peer-review

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Abstract

Background: Congenital anomalies of the kidney and urinary tract (CAKUT) are defined as structural malformations of the kidney and/or urinary tract. Heat shock proteins (HSPs) are expressed in the kidney in response to cellular changes, such as thermal, hemodynamic, osmotic, inflammatory, and mechanical stresses. This study aimed to assess uHSP70 levels during acute urinary tract infections (UTI) and non-infection periods in patients with CAKUT, and to evaluate whether uHSP70 is elevated in CAKUT subtypes. Methods: Among patients with CAKUT, 89 patients with UTI (CAKUT-A), 111 without UTI (CAKUT-B), and 74 healthy children were included in the study. uHSP70 levels were measured using enzyme-linked immunosorbent assay (ELISA). Results: uHSP70 level was significantly higher in the CAKUT-A group than in the CAKUT-B and healthy control groups (p < 0.0001). Moreover, the level of uHSP70 was significantly higher in the CAKUT-B group than in the control group (p < 0.0001), but was not different between the CAKUT subtypes (p > 0.05). Conclusion: Urine HSP70 can also be used to predict UTI in patients with CAKUT. Moreover, uHSP70 levels were higher in children with CAKUT during the non-infectious period than in healthy controls. This suggests that children with CAKUT are at risk of chronic non-infectious damage.

Original language	English
Article number	1281081
Journal	Frontiers in Urology
Volume	3
DOIs	https://doi.org/10.3389/fruro.2023.1281081
Publication status	Published - 2023
Externally published	Yes

Keywords

CAKUT
Hsp70
UTILISE study
children
congenital anomalies of the kidney and urinary tract
heat shock proteins

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10.3389/fruro.2023.1281081

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Aksu, B., Afonso, A. C., Akil, I., Alpay, H., Atmis, B., Aydog, O., Bakkaloglu, S., Bayazıt, A. K., Bayram, M. T., Bilge, I., Bulut, I. K., Cetinkaya, A. P. G., Comak, E., Demir, B. K., Dincel, N., Donmez, O., Durmus, M. A., Dursun, H., Dusunsel, R., ... Yilmaz, A. (2023). The relationship between urine heat shock protein 70 and congenital anomalies of the kidney and urinary tract: UTILISE study. Frontiers in Urology, 3, Article 1281081. https://doi.org/10.3389/fruro.2023.1281081

@article{26e5b9298bf34d689fd562834acc5497,

title = "The relationship between urine heat shock protein 70 and congenital anomalies of the kidney and urinary tract: UTILISE study",

abstract = "Background: Congenital anomalies of the kidney and urinary tract (CAKUT) are defined as structural malformations of the kidney and/or urinary tract. Heat shock proteins (HSPs) are expressed in the kidney in response to cellular changes, such as thermal, hemodynamic, osmotic, inflammatory, and mechanical stresses. This study aimed to assess uHSP70 levels during acute urinary tract infections (UTI) and non-infection periods in patients with CAKUT, and to evaluate whether uHSP70 is elevated in CAKUT subtypes. Methods: Among patients with CAKUT, 89 patients with UTI (CAKUT-A), 111 without UTI (CAKUT-B), and 74 healthy children were included in the study. uHSP70 levels were measured using enzyme-linked immunosorbent assay (ELISA). Results: uHSP70 level was significantly higher in the CAKUT-A group than in the CAKUT-B and healthy control groups (p < 0.0001). Moreover, the level of uHSP70 was significantly higher in the CAKUT-B group than in the control group (p < 0.0001), but was not different between the CAKUT subtypes (p > 0.05). Conclusion: Urine HSP70 can also be used to predict UTI in patients with CAKUT. Moreover, uHSP70 levels were higher in children with CAKUT during the non-infectious period than in healthy controls. This suggests that children with CAKUT are at risk of chronic non-infectious damage.",

keywords = "CAKUT, Hsp70, UTILISE study, children, congenital anomalies of the kidney and urinary tract, heat shock proteins",

author = "Bagdagul Aksu and Afonso, {Alberto Caldas} and Ipek Akil and Harika Alpay and Bahriye Atmis and Ozlem Aydog and Sevcan Bakkaloglu and Bayazıt, {Aysun Karabay} and Bayram, {Meral Torun} and Ilmay Bilge and Bulut, {Ipek Kaplan} and Cetinkaya, {Ayse Pinar Goksu} and Elif Comak and Demir, {Belde Kasap} and Nida Dincel and Osman Donmez and Durmus, {Mehmet Akif} and Hasan Dursun and Ruhan Dusunsel and Ali Duzova and Pelin Ertan and Asuman Gedikbasi and Nilufer Goknar and Sercin Guven and Duygu Hacihamdioglu and Augustina Jankauskiene and Mukaddes Kalyoncu and Salih Kavukcu and Kenan, {Bahriye Uzun} and Nuran Kucuk and Bahar Kural and Mieczys{\l}aw Litwin and Giovanni Montini and William Morello and Lukasz Obrycki and Beyhan Omer and {Misirli Ozdemir}, Ebru and Nese Ozkayin and Dusan Paripovic and Cemile Pehlivanoglu and Seha Saygili and Franz Schaefer and Susanne Schaefer and Ferah Sonmez and Yilmaz Tabel and Nesrin Tas and Mehmet Tasdemir and Ana Teixeira and Demet Tekcan and Rezan Topaloglu and Sebahat Tulpar and Turkkan, {Ozde Nisa} and Berfin Uysal and Metin Uysalol and Renata Vitkevic and Sevgi Yavuz and Sibel Yel and Tarik Yildirim and Yildirim, {Zeynep Yuruk} and Nurdan Yildiz and Selcuk Yuksel and Eray Yurtseven and Alev Yilmaz",

note = "Publisher Copyright: Copyright {\textcopyright} 2024 Aksu, Afonso, Akil, Alpay, Atmis, Aydog, Bakkaloglu, Bayazıt, Bayram, Bilge, Bulut, Cetinkaya, Comak, Demir, Dincel, Donmez, Durmus, Dursun, Dusunsel, Duzova, Ertan, Gedikbasi, Goknar, Guven, Hacihamdioglu, Jankauskiene, Kalyoncu, Kavukcu, Kenan, Kucuk, Kural, Litwin, Montini, Morello, Obrycki, Omer, Misirli Ozdemir, Ozkayin, Paripovic, Pehlivanoglu, Saygili, Schaefer, Schaefer, Sonmez, Tabel, Tas, Tasdemir, Teixeira, Tekcan, Topaloglu, Tulpar, Turkkan, Uysal, Uysalol, Vitkevic, Yavuz, Yel, Yildirim, Yildirim, Yildiz, Yuksel, Yurtseven and Yilmaz.",

year = "2023",

doi = "10.3389/fruro.2023.1281081",

language = "English",

volume = "3",

journal = "Frontiers in Urology",

issn = "2673-9828",

publisher = "Frontiers Media SA",

}

Aksu, B, Afonso, AC, Akil, I, Alpay, H, Atmis, B, Aydog, O, Bakkaloglu, S, Bayazıt, AK, Bayram, MT, Bilge, I, Bulut, IK, Cetinkaya, APG, Comak, E, Demir, BK, Dincel, N, Donmez, O, Durmus, MA, Dursun, H, Dusunsel, R, Duzova, A, Ertan, P, Gedikbasi, A, Goknar, N, Guven, S, Hacihamdioglu, D, Jankauskiene, A, Kalyoncu, M, Kavukcu, S, Kenan, BU, Kucuk, N, Kural, B, Litwin, M, Montini, G, Morello, W, Obrycki, L, Omer, B, Misirli Ozdemir, E, Ozkayin, N, Paripovic, D, Pehlivanoglu, C, Saygili, S, Schaefer, F, Schaefer, S, Sonmez, F, Tabel, Y, Tas, N, Tasdemir, M, Teixeira, A, Tekcan, D, Topaloglu, R, Tulpar, S, Turkkan, ON, Uysal, B, Uysalol, M, Vitkevic, R, Yavuz, S, Yel, S, Yildirim, T, Yildirim, ZY, Yildiz, N, Yuksel, S, Yurtseven, E & Yilmaz, A 2023, 'The relationship between urine heat shock protein 70 and congenital anomalies of the kidney and urinary tract: UTILISE study', Frontiers in Urology, vol. 3, 1281081. https://doi.org/10.3389/fruro.2023.1281081

TY - JOUR

T1 - The relationship between urine heat shock protein 70 and congenital anomalies of the kidney and urinary tract

T2 - UTILISE study

AU - Aksu, Bagdagul

AU - Afonso, Alberto Caldas

AU - Akil, Ipek

AU - Alpay, Harika

AU - Atmis, Bahriye

AU - Aydog, Ozlem

AU - Bakkaloglu, Sevcan

AU - Bayazıt, Aysun Karabay

AU - Bayram, Meral Torun

AU - Bilge, Ilmay

AU - Bulut, Ipek Kaplan

AU - Cetinkaya, Ayse Pinar Goksu

AU - Comak, Elif

AU - Demir, Belde Kasap

AU - Dincel, Nida

AU - Donmez, Osman

AU - Durmus, Mehmet Akif

AU - Dursun, Hasan

AU - Dusunsel, Ruhan

AU - Duzova, Ali

AU - Ertan, Pelin

AU - Gedikbasi, Asuman

AU - Goknar, Nilufer

AU - Guven, Sercin

AU - Hacihamdioglu, Duygu

AU - Jankauskiene, Augustina

AU - Kalyoncu, Mukaddes

AU - Kavukcu, Salih

AU - Kenan, Bahriye Uzun

AU - Kucuk, Nuran

AU - Kural, Bahar

AU - Litwin, Mieczysław

AU - Montini, Giovanni

AU - Morello, William

AU - Obrycki, Lukasz

AU - Omer, Beyhan

AU - Misirli Ozdemir, Ebru

AU - Ozkayin, Nese

AU - Paripovic, Dusan

AU - Pehlivanoglu, Cemile

AU - Saygili, Seha

AU - Schaefer, Franz

AU - Schaefer, Susanne

AU - Sonmez, Ferah

AU - Tabel, Yilmaz

AU - Tas, Nesrin

AU - Tasdemir, Mehmet

AU - Teixeira, Ana

AU - Tekcan, Demet

AU - Topaloglu, Rezan

AU - Tulpar, Sebahat

AU - Turkkan, Ozde Nisa

AU - Uysal, Berfin

AU - Uysalol, Metin

AU - Vitkevic, Renata

AU - Yavuz, Sevgi

AU - Yel, Sibel

AU - Yildirim, Tarik

AU - Yildirim, Zeynep Yuruk

AU - Yildiz, Nurdan

AU - Yuksel, Selcuk

AU - Yurtseven, Eray

AU - Yilmaz, Alev

N1 - Publisher Copyright: Copyright © 2024 Aksu, Afonso, Akil, Alpay, Atmis, Aydog, Bakkaloglu, Bayazıt, Bayram, Bilge, Bulut, Cetinkaya, Comak, Demir, Dincel, Donmez, Durmus, Dursun, Dusunsel, Duzova, Ertan, Gedikbasi, Goknar, Guven, Hacihamdioglu, Jankauskiene, Kalyoncu, Kavukcu, Kenan, Kucuk, Kural, Litwin, Montini, Morello, Obrycki, Omer, Misirli Ozdemir, Ozkayin, Paripovic, Pehlivanoglu, Saygili, Schaefer, Schaefer, Sonmez, Tabel, Tas, Tasdemir, Teixeira, Tekcan, Topaloglu, Tulpar, Turkkan, Uysal, Uysalol, Vitkevic, Yavuz, Yel, Yildirim, Yildirim, Yildiz, Yuksel, Yurtseven and Yilmaz.

PY - 2023

Y1 - 2023

N2 - Background: Congenital anomalies of the kidney and urinary tract (CAKUT) are defined as structural malformations of the kidney and/or urinary tract. Heat shock proteins (HSPs) are expressed in the kidney in response to cellular changes, such as thermal, hemodynamic, osmotic, inflammatory, and mechanical stresses. This study aimed to assess uHSP70 levels during acute urinary tract infections (UTI) and non-infection periods in patients with CAKUT, and to evaluate whether uHSP70 is elevated in CAKUT subtypes. Methods: Among patients with CAKUT, 89 patients with UTI (CAKUT-A), 111 without UTI (CAKUT-B), and 74 healthy children were included in the study. uHSP70 levels were measured using enzyme-linked immunosorbent assay (ELISA). Results: uHSP70 level was significantly higher in the CAKUT-A group than in the CAKUT-B and healthy control groups (p < 0.0001). Moreover, the level of uHSP70 was significantly higher in the CAKUT-B group than in the control group (p < 0.0001), but was not different between the CAKUT subtypes (p > 0.05). Conclusion: Urine HSP70 can also be used to predict UTI in patients with CAKUT. Moreover, uHSP70 levels were higher in children with CAKUT during the non-infectious period than in healthy controls. This suggests that children with CAKUT are at risk of chronic non-infectious damage.

AB - Background: Congenital anomalies of the kidney and urinary tract (CAKUT) are defined as structural malformations of the kidney and/or urinary tract. Heat shock proteins (HSPs) are expressed in the kidney in response to cellular changes, such as thermal, hemodynamic, osmotic, inflammatory, and mechanical stresses. This study aimed to assess uHSP70 levels during acute urinary tract infections (UTI) and non-infection periods in patients with CAKUT, and to evaluate whether uHSP70 is elevated in CAKUT subtypes. Methods: Among patients with CAKUT, 89 patients with UTI (CAKUT-A), 111 without UTI (CAKUT-B), and 74 healthy children were included in the study. uHSP70 levels were measured using enzyme-linked immunosorbent assay (ELISA). Results: uHSP70 level was significantly higher in the CAKUT-A group than in the CAKUT-B and healthy control groups (p < 0.0001). Moreover, the level of uHSP70 was significantly higher in the CAKUT-B group than in the control group (p < 0.0001), but was not different between the CAKUT subtypes (p > 0.05). Conclusion: Urine HSP70 can also be used to predict UTI in patients with CAKUT. Moreover, uHSP70 levels were higher in children with CAKUT during the non-infectious period than in healthy controls. This suggests that children with CAKUT are at risk of chronic non-infectious damage.

KW - CAKUT

KW - Hsp70

KW - UTILISE study

KW - children

KW - congenital anomalies of the kidney and urinary tract

KW - heat shock proteins

UR - http://www.scopus.com/inward/record.url?scp=85187893854&partnerID=8YFLogxK

U2 - 10.3389/fruro.2023.1281081

DO - 10.3389/fruro.2023.1281081

M3 - Article

AN - SCOPUS:85187893854

SN - 2673-9828

VL - 3

JO - Frontiers in Urology

JF - Frontiers in Urology

M1 - 1281081

ER -

The relationship between urine heat shock protein 70 and congenital anomalies of the kidney and urinary tract: UTILISE study

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