TY - JOUR
T1 - Urinary netrin-1
T2 - A new biomarker for the early diagnosis of renal damage in obese children
AU - Hacıhamdioğlu, Duygu Övünç
AU - Hacıhamdioğlu, Bülent
AU - Altun, Demet
AU - Müftüoğlu, Tuba
AU - Karademir, Ferhan
AU - Süleymanoğlu, Selami
N1 - Publisher Copyright:
© Journal of Clinical Research in Pediatric Endocrinology.
PY - 2016/9
Y1 - 2016/9
N2 - Objective: Urinary netrin-1 is a new marker to demonstrate early tubular damage. The aim of this study was to determine whether urinary netrin-1 is increased in obese children. Methods: A total of 68 normoalbuminuric and normotensive obese patients and 65 controls were included in the study. Urine samples were collected for assessment of urinary phosphorus, sodium, potassium, creatinine, albumin, and netrin-1. Blood samples were collected for measurements of fasting glucose, insulin, lipid, phosphorus, sodium, potassium, and creatinine levels. Homeostatic model assessment insulin resistance index was calculated. Results: Gender and age were similar between obese and control groups (12.01±3.03 vs. 11.7±3.2 years, p=0.568 and 33 vs. 35 girls, p=0.543, respectively). Obese patients had significantly higher netrin-1 excretion than the controls (841.68±673.17 vs. 228.94±137.25 pg/mg creatinine, p=0.000). Urinary netrin-1 level was significantly higher in obese subjects with insulin resistance compared to those without insulin resistance (1142±1181 vs. 604.9±589.91 pg/mg creatinine, p=0.001). Conclusion: In normotensive and normoalbuminuric obese children, urinary netrin-1 level can increase before onset of albuminuria. Urinary netrin-1 excretion appears to be affected predominantly by insulin resistance and hyperinsulinemia. Urinary netrin-1 may be a new biomarker for determining early tubular injury in obese children.
AB - Objective: Urinary netrin-1 is a new marker to demonstrate early tubular damage. The aim of this study was to determine whether urinary netrin-1 is increased in obese children. Methods: A total of 68 normoalbuminuric and normotensive obese patients and 65 controls were included in the study. Urine samples were collected for assessment of urinary phosphorus, sodium, potassium, creatinine, albumin, and netrin-1. Blood samples were collected for measurements of fasting glucose, insulin, lipid, phosphorus, sodium, potassium, and creatinine levels. Homeostatic model assessment insulin resistance index was calculated. Results: Gender and age were similar between obese and control groups (12.01±3.03 vs. 11.7±3.2 years, p=0.568 and 33 vs. 35 girls, p=0.543, respectively). Obese patients had significantly higher netrin-1 excretion than the controls (841.68±673.17 vs. 228.94±137.25 pg/mg creatinine, p=0.000). Urinary netrin-1 level was significantly higher in obese subjects with insulin resistance compared to those without insulin resistance (1142±1181 vs. 604.9±589.91 pg/mg creatinine, p=0.001). Conclusion: In normotensive and normoalbuminuric obese children, urinary netrin-1 level can increase before onset of albuminuria. Urinary netrin-1 excretion appears to be affected predominantly by insulin resistance and hyperinsulinemia. Urinary netrin-1 may be a new biomarker for determining early tubular injury in obese children.
KW - Children
KW - Insulin resistance
KW - Netrin-1
KW - Obesity
KW - Tubular dysfunction
UR - http://www.scopus.com/inward/record.url?scp=84985038519&partnerID=8YFLogxK
U2 - 10.4274/jcrpe.2828
DO - 10.4274/jcrpe.2828
M3 - Article
C2 - 27087488
AN - SCOPUS:84985038519
SN - 1308-5727
VL - 8
SP - 282
EP - 287
JO - JCRPE Journal of Clinical Research in Pediatric Endocrinology
JF - JCRPE Journal of Clinical Research in Pediatric Endocrinology
IS - 3
ER -
