TY - JOUR
T1 - Deterioration of heart rate recovery index in patients with erectile dysfunction
AU - Ulucan, Şeref
AU - Kaya, Zeynettin
AU - Keser, Ahmet
AU - Katlandur, Hüseyin
AU - Karanfil, Mustafa
AU - Ateş, İsmail
N1 - Publisher Copyright:
© 2016 by Turkish Society of Cardiology.
PY - 2016
Y1 - 2016
N2 - Objective: Heart rate recovery (HHR) after exercise is a function of vagal reactivation. This study aimed to evaluate HHR index in patients with erectile dysfunction. Methods: Men over the age of 18 years who were diagnosed with erectile dysfunction were included in the study. Ninety patients with erectile dysfunction (mean age=56.1±8.3 years) and 50 healthy subjects as controls (mean age=53.1±10.4 years) were compared. The erectile status of patients was evaluated using the sexual health inventory for men questionnaire. Basal electrocardiography, echocardiography, and treadmill exercise testing were performed in all patients and controls. The HHR index was defined as the reduction in heart rate from the rate at peak exercise to the rate at the first minute (HRR1), second minute (HRR2), third minute (HRR3), and fifth minute (HRR5) after terminating exercise stress testing. An independent sample t-test, Pearson correlation coefficient test, linear multivariate regression analysis, and receiver operating characteristic curve analysis were used for statistical assessment. Results: All HHR indices were found to be significantly decreased in patients with erectile dysfunction (p<0.001). Effort capacity was markedly lower (9.1±2.3 vs. 10.4±2.3 METs, p=0.002) among patients with erectile dysfunction. HRR1 and HRR3 were found to be an independent risk factor for erectile dysfunction (Beta=0.462, p<0.001; Beta=0.403, p<0.001; respectively) in linear regression analysis. Conclusion: Decreased HHR index may be considered as one of the independent predictors of impaired autonomic function in patients with erectile dysfunction.
AB - Objective: Heart rate recovery (HHR) after exercise is a function of vagal reactivation. This study aimed to evaluate HHR index in patients with erectile dysfunction. Methods: Men over the age of 18 years who were diagnosed with erectile dysfunction were included in the study. Ninety patients with erectile dysfunction (mean age=56.1±8.3 years) and 50 healthy subjects as controls (mean age=53.1±10.4 years) were compared. The erectile status of patients was evaluated using the sexual health inventory for men questionnaire. Basal electrocardiography, echocardiography, and treadmill exercise testing were performed in all patients and controls. The HHR index was defined as the reduction in heart rate from the rate at peak exercise to the rate at the first minute (HRR1), second minute (HRR2), third minute (HRR3), and fifth minute (HRR5) after terminating exercise stress testing. An independent sample t-test, Pearson correlation coefficient test, linear multivariate regression analysis, and receiver operating characteristic curve analysis were used for statistical assessment. Results: All HHR indices were found to be significantly decreased in patients with erectile dysfunction (p<0.001). Effort capacity was markedly lower (9.1±2.3 vs. 10.4±2.3 METs, p=0.002) among patients with erectile dysfunction. HRR1 and HRR3 were found to be an independent risk factor for erectile dysfunction (Beta=0.462, p<0.001; Beta=0.403, p<0.001; respectively) in linear regression analysis. Conclusion: Decreased HHR index may be considered as one of the independent predictors of impaired autonomic function in patients with erectile dysfunction.
KW - Autonomic nervous system
KW - Erectile dysfunction
KW - Exercise test
KW - Heart rate recovery index
UR - http://www.scopus.com/inward/record.url?scp=84994246558&partnerID=8YFLogxK
U2 - 10.5152/AnatolJCardiol.2015.6132
DO - 10.5152/AnatolJCardiol.2015.6132
M3 - Article
C2 - 26642469
AN - SCOPUS:84994246558
SN - 2149-2263
VL - 16
SP - 264
EP - 269
JO - Anatolian Journal of Cardiology
JF - Anatolian Journal of Cardiology
IS - 4
ER -