iCELLigence real-time cell analysis system for examining the cytotoxicity of drugs to cancer cell lines

Leyla Türker Şener; Gürcan Albeniz; Bircan Dinç; Işil Albeniz

doi:10.3892/etm.2017.4781

iCELLigence real-time cell analysis system for examining the cytotoxicity of drugs to cancer cell lines

Leyla Türker Şener, Gürcan Albeniz, Bircan Dinç, Işil Albeniz

Araştırma sonucu: Dergi katkısı › Derleme makalesi › bilirkişi

48 Alıntılar (Scopus)

Özet

The recently developed iCELLigence™ real-time cell analyzer (RTCA) can be used for the label-free real-time monitoring of cancer cell proliferation, viability, invasion and cytotoxicity. The RTCA system uses 16-well microtiter plates with a gold microelectrode biosensor array that measures impedance when cells adhere to the microelectrodes causing an alternating current. By measuring the electric field generated in this process, the RTCA system can be used for the analysis of cell proliferation, viability, morphology and migration. The present review aimed to summarize the working method of the RTCA system, in addition to discussing the research performed using the system for various applications, including cancer drug discovery via measuring cytotoxicity.

Orijinal dil	İngilizce
Sayfa (başlangıç-bitiş)	1866-1870
Sayfa sayısı	5
Dergi	Experimental and Therapeutic Medicine
Hacim	14
Basın numarası	3
DOI'lar	https://doi.org/10.3892/etm.2017.4781
Yayın durumu	Yayınlanan - 2017
Harici olarak yayınlandı	Evet

BM SKH

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Belgeye Erişim

10.3892/etm.2017.4781

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title = "iCELLigence real-time cell analysis system for examining the cytotoxicity of drugs to cancer cell lines",

abstract = "The recently developed iCELLigence{\texttrademark} real-time cell analyzer (RTCA) can be used for the label-free real-time monitoring of cancer cell proliferation, viability, invasion and cytotoxicity. The RTCA system uses 16-well microtiter plates with a gold microelectrode biosensor array that measures impedance when cells adhere to the microelectrodes causing an alternating current. By measuring the electric field generated in this process, the RTCA system can be used for the analysis of cell proliferation, viability, morphology and migration. The present review aimed to summarize the working method of the RTCA system, in addition to discussing the research performed using the system for various applications, including cancer drug discovery via measuring cytotoxicity.",

keywords = "Cellular impedance, Cytotoxicity, MCF-7, MDA-MB-231, Proliferation, iCELLigence, xCELLigence",

author = "{\c S}ener, {Leyla T{\"u}rker} and G{\"u}rcan Albeniz and Bircan Din{\c c} and I{\c s}il Albeniz",

year = "2017",

doi = "10.3892/etm.2017.4781",

language = "English",

volume = "14",

pages = "1866--1870",

journal = "Experimental and Therapeutic Medicine",

issn = "1792-0981",

publisher = "Spandidos Publications",

number = "3",

}

TY - JOUR

T1 - iCELLigence real-time cell analysis system for examining the cytotoxicity of drugs to cancer cell lines

AU - Şener, Leyla Türker

AU - Albeniz, Gürcan

AU - Dinç, Bircan

AU - Albeniz, Işil

PY - 2017

Y1 - 2017

N2 - The recently developed iCELLigence™ real-time cell analyzer (RTCA) can be used for the label-free real-time monitoring of cancer cell proliferation, viability, invasion and cytotoxicity. The RTCA system uses 16-well microtiter plates with a gold microelectrode biosensor array that measures impedance when cells adhere to the microelectrodes causing an alternating current. By measuring the electric field generated in this process, the RTCA system can be used for the analysis of cell proliferation, viability, morphology and migration. The present review aimed to summarize the working method of the RTCA system, in addition to discussing the research performed using the system for various applications, including cancer drug discovery via measuring cytotoxicity.

AB - The recently developed iCELLigence™ real-time cell analyzer (RTCA) can be used for the label-free real-time monitoring of cancer cell proliferation, viability, invasion and cytotoxicity. The RTCA system uses 16-well microtiter plates with a gold microelectrode biosensor array that measures impedance when cells adhere to the microelectrodes causing an alternating current. By measuring the electric field generated in this process, the RTCA system can be used for the analysis of cell proliferation, viability, morphology and migration. The present review aimed to summarize the working method of the RTCA system, in addition to discussing the research performed using the system for various applications, including cancer drug discovery via measuring cytotoxicity.

KW - Cellular impedance

KW - Cytotoxicity

KW - MCF-7

KW - MDA-MB-231

KW - Proliferation

KW - iCELLigence

KW - xCELLigence

UR - http://www.scopus.com/inward/record.url?scp=85026649914&partnerID=8YFLogxK

U2 - 10.3892/etm.2017.4781

DO - 10.3892/etm.2017.4781

M3 - Review article

AN - SCOPUS:85026649914

SN - 1792-0981

VL - 14

SP - 1866

EP - 1870

JO - Experimental and Therapeutic Medicine

JF - Experimental and Therapeutic Medicine

IS - 3

ER -

iCELLigence real-time cell analysis system for examining the cytotoxicity of drugs to cancer cell lines

Özet

BM SKH

Belgeye Erişim

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