Obezite ile aort elastikiyeti arasindaki IliSki

Objective: Obesity is known to play a key role in the development of coronary heart disease. Beside this, aortic distensibility and aortic stiffness index can be used for early detection of atherosclerosis. Our aim is to present aortic elastic properties in obesity and also to present the factors that damage aortic distensibility and increase aortic stiffness index. Material and Methods: Totally 96 cases of whom 12 were with normal [body mass index (BMI) <25)] weight, 17 were overweight (BMI: 25-29.9), 43 patients were obese (BMI: 30-39.9) and 24 were morbid obese patients (BMI ?40) according to World Health Organization were included to present study. For statistical analysis, according to the 30 kg/ m2 of accepted cut-off value for obesity, patients were evaluated by dividing to two groups of BMI <30 kg/ m2 and BMI ?30 kg/m2. After performing the blood analysis of the patients, aortic stiffness, aortic distensibility, and aortic stiffness index were calculated by echocardiographic measurements. Results: In parallel to weight increment from normal weight to morbid obesity aortic stiffness and distensibility were decreased and stiffness index was increased (decrement in distensibility 0.31±}0.2 and 0.16±}0.3 p= 0.015, increase in stiffness index 0.07±}0.24 and 0.12±}0.4, p=0.029). Although there was not a change in white blood cell count and netrophil/lymphocyte ratio as markers of acute inflammation, it was seen that there was a significant increase in subacute inflammation marker C-reactive protein levels (1.28±}0.6 and 2.97±}1.8 respectively, p<0.001). There was a positive correlation between aortic stiffness index and weight (r: 0.250, p: 0.014), age (r: 0.205, p:0.045), systolic blood pressure (r: 0.224, p: 0.028) and diastolic radius of aorta (r: 0.374, p<0.001). Conclusion: In obesity, aortic stiffness index was significantly increasing and distensibility was decreasing in parallel to weight increment. Calculation of these easily measured parameters especially in morbid obese individuals might help in the early recognition of atherosclerosis.