Prenatal bisphenol a and phthalate exposure are risk factors for male reproductive system development and cord blood sex hormone levels

Birce Sunman, Kadriye Yurdakök, Belma Kocer-Gumusel, Özgür Özyüncü, Filiz Akbıyık, Aylin Balcı, Gizem Özkemahlı, Pınar Erkekoğlu, Murat Yurdakök

Araştırma sonucu: Dergi katkısıMakalebilirkişi

45 Alıntılar (Scopus)

Özet

Bisphenol A (BPA) and phthalates can adversely affect the fetal development. However, observational studies on the effects of these chemicals on fetal male reproductive system are still limited. A hundred of umbilical cord blood samples were analyzed for the levels of BPA, di-2-ethylhexyl phthalate (DEHP), mono-2-ethylhexyl phthalate (MEHP), and sex hormones. After birth, male newborns underwent physical examination that included measurements of anogenital distance, stretched penile length (SPL), and penile width. BPA, DEHP and MEHP levels were detectable in ≈99% of cord blood samples. In covariate-adjusted models, cord blood BPA levels were inversely associated with SPL of newborns and positively associated with cord blood estradiol levels. In addition, there was a significant inverse relationship between cord blood DEHP levels and anogenital distance index of newborn males. Our results suggest that in utero BPA and DEHP exposure exerted adverse effects on fetal male reproductive development and cord blood estradiol levels.

Orijinal dilİngilizce
Sayfa (başlangıç-bitiş)146-155
Sayfa sayısı10
DergiReproductive Toxicology
Hacim87
DOI'lar
Yayın durumuYayınlanan - Ağu 2019
Harici olarak yayınlandıEvet

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