TY - JOUR
T1 - Toxic effects of Aroclor 1254 on rat liver and modifying roles of selenium
AU - Balcı Özyurt, Aylin
AU - Erkekoğlu, Pınar
AU - Zeybek, Naciye Dilara
AU - Aşcı, Ali
AU - Yaman, Ünzile
AU - Oflaz, Ofcan
AU - Kızılgün, Murat
AU - İşcan, Evin
AU - Batur, Tuğçe
AU - Öztürk, Mehmet
AU - Koçer-Gümüşel, Belma
N1 - Publisher Copyright:
© 2023 Informa UK Limited, trading as Taylor & Francis Group.
PY - 2023
Y1 - 2023
N2 - Polychlorinated biphenyls (PCBs) were used in different industrial areas and banned due to their high toxicity. Aroclor 1254 (A1254), commercial PCB congener, accumulates in environment leading to high human exposure. A1254 may cause hepatotoxicity, metabolic and endocrine disorders. In our study, 3-week-old male rats were separated into 6 groups: C (0.15 mg/kg Se in diet); SeS (1 mg/kg Se in diet); SeD (0.05 mg/kg Se in diet); A1254 receiving groups (A; ASeS; ASeD) were given 10 mg/kg/day A1254 orally for last 15 days of feeding period with control, SeD or SeS diet, respectively, for 5 weeks. Histopathology, oxidant/antioxidant balance, apoptosis and cell cycle proteins (p53, p21) in liver were evaluated. Our results suggest that A1254 leads to changes in histology, oxidative stress and apoptosis. Selenium deficiency augments oxidative stress and apoptosis while selenium supplementation is partially protective. More mechanistic in vivo experiments are necessary for evaluation of hepatotoxicity of PCBs.
AB - Polychlorinated biphenyls (PCBs) were used in different industrial areas and banned due to their high toxicity. Aroclor 1254 (A1254), commercial PCB congener, accumulates in environment leading to high human exposure. A1254 may cause hepatotoxicity, metabolic and endocrine disorders. In our study, 3-week-old male rats were separated into 6 groups: C (0.15 mg/kg Se in diet); SeS (1 mg/kg Se in diet); SeD (0.05 mg/kg Se in diet); A1254 receiving groups (A; ASeS; ASeD) were given 10 mg/kg/day A1254 orally for last 15 days of feeding period with control, SeD or SeS diet, respectively, for 5 weeks. Histopathology, oxidant/antioxidant balance, apoptosis and cell cycle proteins (p53, p21) in liver were evaluated. Our results suggest that A1254 leads to changes in histology, oxidative stress and apoptosis. Selenium deficiency augments oxidative stress and apoptosis while selenium supplementation is partially protective. More mechanistic in vivo experiments are necessary for evaluation of hepatotoxicity of PCBs.
KW - Polychlorinated biphenyls
KW - apoptosis
KW - liver
KW - oxidative stress
KW - selenium
UR - http://www.scopus.com/inward/record.url?scp=85161889553&partnerID=8YFLogxK
U2 - 10.1080/09603123.2023.2223470
DO - 10.1080/09603123.2023.2223470
M3 - Article
C2 - 37309736
AN - SCOPUS:85161889553
SN - 0960-3123
VL - 33
SP - 1289
EP - 1304
JO - International Journal of Environmental Health Research
JF - International Journal of Environmental Health Research
IS - 12
ER -